✔ 100% Authentic Product
👁️ Currently Viewing 33
Obexa 10mg Tablet 1 Strip
Obexa is prescribed for adults diagnosed with Primary Biliary Cholangitis (PBC) who either:
- Do not have cirrhosis, or
- Have compensated cirrhosis without signs of portal hypertension.
- It can be used:
- In combination with ursodeoxycholic acid (UDCA) when the response to UDCA alone is insufficient, or
- As monotherapy in patients intolerant to UDCA.
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
Cash on Delivery - All over Bangladesh
Regular Delivery - 8-12 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
✅ Description:
Obeticholic acid activates the Farnesoid X Receptor (FXR) found in the liver and intestines. FXR plays a crucial role in controlling bile acid levels, inflammation, fibrosis, and metabolism. Its activation reduces bile acid build-up in liver cells by:
- Suppressing bile acid synthesis from cholesterol
- Enhancing their excretion from hepatocytes
- This action reduces the circulating bile acid pool and encourages bile flow, lowering hepatic bile acid exposure.
Pharmacodynamics:
Daily dosing with 10 mg obeticholic acid led to a 173% rise in FGF-19, a bile-regulating hormone, over 12 months. It also reduced levels of cholic acid and chenodeoxycholic acid. The clinical implications of these changes remain unclear.
Cardiac Safety:
No significant QT interval prolongation was observed at doses up to 10 times the recommended level.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️
✔️ Dosage & Administration
Pre-treatment Assessment:
Before starting therapy, assess for:
Decompensated cirrhosis (Child-Pugh Class B/C)
Previous hepatic decompensation
Portal hypertension (e.g., ascites, varices, low platelets)
Obexa is contraindicated in such cases.
Recommended Dosage:
Start at 5 mg once daily for 3 months.
If necessary and tolerated, increase to 10 mg once daily based on liver function tests (ALP and bilirubin).
- Pediatrics: Not established for children.
- Elderly (65+ years): No major safety differences noted, but increased sensitivity is possible.
- Hepatic Impairment: Contraindicated in decompensated liver disease or portal hypertension due tothe risk of serious hepatic side effects.
✔️ Managing Severe Pruritus:
Consider adding antihistamines or bile acid sequestrants.
Modify dose:
• 5 mg every other day (if 5 mg daily is not tolerated)
• 5 mg daily (if 10 mg daily is intolerable)
Interrupt therapy temporarily (up to 2 weeks) and resume at a lower dose if needed.
✔️ Monitoring:
- Regularly monitor liver biochemistry and signs of worsening PBC.
- Patients with cirrhosis or concurrent liver disease should be watched closely for portal hypertension or hepatic decompensation.
- Discontinue if evidence of liver failure, biliary obstruction, or severe hepatic events arises.
✔️ Side Effects
Common adverse effects include:
Itching (pruritus)
Fatigue
Abdominal discomfort
Others: rash, joint pain, throat irritation, dizziness, constipation, thyroid irregularities, and skin inflammation (eczema)
✔️ Drug Interactions
- Bile Acid Binding Agents (e.g., cholestyramine) may interfere with Obexa absorption. Space doses by at least 4 hours.
- Warfarin May reduce INR. Monitor and adjust warfarin dose.
- CYP1A2 Substrates (e.g., theophylline): Obexa may elevate their blood levels. Therapeutic drug monitoring is advised.
- BSEP Inhibitors (e.g., cyclosporine): Concomitant use may raise hepatic bile salt accumulation. Use with caution and monitor liver function.
✔️ Contraindications
Decompensated cirrhosis or history of liver decompensation
Portal hypertension in compensated cirrhosis
Complete bile duct obstruction
✔️ Use in Pregnancy and Lactation
Pregnancy:
Limited human data. Animal studies show no harm at high doses. Use only if needed.
Lactation:
Unknown if excreted in breast milk. Weigh the benefits of breastfeeding against the mother's treatment needs and potential risk to the infant.
✔️ Precautions & Warnings
Liver Complications in Cirrhosis:
Liver failure and decompensation, some fatal or requiring transplant, have occurred, especially in cirrhotic patients. Risk increases with higher doses or pre-existing liver issues. Monitor liver function closely.
Severe Itching:
Occurs in up to 23% of patients at the 10 mg dose. It can severely affect daily life. Consider dose adjustment, symptomatic treatment, or interruption of therapy.
HDL-C Reduction:
Obexa may lower HDL (good cholesterol). Monitor lipid levels, particularly in long-term use or when treatment response is poor.
✔️ Overdose
Higher-than-recommended doses (25–50 mg) have led to liver-related side effects. If overdose occurs, provide supportive treatment and monitor liver function closely.
✔️ Storage
Store below 30°C, in a dry, dark place. Keep away from the child
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
